This research paves the way for further biotechnological development and fundamental understanding of methylotrophy in the preeminent eukaryotic model organism and industrial workhorse, S. A systems biology approach reveals that global rearrangements in central carbon metabolism fluxes, gene expression changes, and a truncation of the uncharacterized transcriptional regulator Ygr067cp supports improved methylotrophy in laboratory evolved S. cerevisiae has a native capacity for methylotrophy. Here, using adaptive laboratory evolution and 13C-tracer analysis, we discover that S. However, its ability to metabolize methanol has been poorly characterised. Saccharomyces cerevisiae is an important industrial microorganism for which growth on one-carbon substrates would be relevant. Methylotrophic metabolism enables growth and energy generation from methanol, providing an alternative to sugar fermentation. Utilising one-carbon substrates such as carbon dioxide, methane, and methanol is vital to address the current climate crisis.
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